The short version
Semaglutide and tirzepatide are both compounded GLP-1 weight loss treatments, prescribed by licensed providers and dispensed by licensed pharmacies. Both are taken as a weekly injection, and both are priced by your prescribed dose. The main differences are how they work, the average results seen in studies, and the price.
How each one works
Semaglutide mimics GLP-1, a hormone your body makes naturally that helps regulate appetite and blood sugar. It helps you feel full sooner and stay full longer, so eating less feels easier.
Tirzepatide works on two appetite pathways at once — GLP-1 and GIP. That dual action is why it produced the strongest average results in clinical studies.
Average results in clinical studies
In clinical studies of the branded medications, patients on semaglutide lost about 15% of their body weight on average, and patients on tirzepatide lost about 20% on average over the 72-week study. These are averages from studies of the branded medications — your own results depend on your dose, your health, and how your body responds.
Price by dose
| Program | Weekly dose | Monthly price |
|---|---|---|
| Semaglutide Dose 1 | 0.25 mg | $230 |
| Semaglutide Dose 2 | 0.5 mg | $230 |
| Semaglutide Dose 3 | 1 mg | $250 |
| Semaglutide Dose 4 | 1.5 mg | $270 |
| Semaglutide Dose 5 | 2.5 mg | $290 |
| Tirzepatide Dose 1 | 2.5 mg | $297 |
| Tirzepatide Dose 2 | 5 mg | $297 |
| Tirzepatide Dose 3 | 7.5 mg | $305 |
| Tirzepatide Dose 4 | 10 mg | $320 |
| Tirzepatide Dose 5 | 12.5 mg | $340 |
| Tirzepatide Dose 6 | 15 mg | $380 |
Every program starts at the lowest dose, and your provider adjusts the dose as your body responds. See the full breakdown in our guide to how much compounded GLP-1 costs.
So which one should you choose?
You don't have to decide alone — and you don't pay to find out. Complete a free intake, and a licensed provider reviews your health history and decides which medication and dose are safe and appropriate for you. You're charged only if you're approved, and if a provider denies your prescription, you get your money back — guaranteed.
Start with a free consultation
Pick a treatment to request, complete your free intake, and let a licensed provider make the call.
View Semaglutide — from $230/mo View Tirzepatide — from $297/moPrescription treatment requires clinical review. Exploring a product does not establish eligibility or start treatment. Compounded medications are not FDA-approved products. Full program details are on our medical weight loss page.